PPO-allene

PPO-allene is a covalent botulinum neurotoxin (BoNT) light chain inhibitor (IC50: 20.9 μM) . PPO-allene (0.3 mg/kg, i.v.) demonstrates an in vivo half-life of approximately 1.5 h in mice[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Neurological Disease

Smiles

O=C1C=C(N=C2C(O)=C(C=CN21)CCCNC(C=C=C)=O)CNCC3=CC=C(C=C3)C4=CC=CC=C4

Molecular Formula

C29H28N4O3

Molecular Weight

480.56

References & Citations

[1]Lin M, et al. Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site. J Med Chem. 2025 Apr 24;68 (8) :8796-8816.