Rapaglutin E
Rapaglutin E (RgE) is a glucose transporter (GLUT) inhibitor. Rapaglutin E exhibits dose-dependent inhibition of [3H]-2DG uptake in A549, Jurkat T, PANC10.05, and RBC, with IC50 values 8.9 nM, 3.1 nM, 35.5 nM, 74.2 nM. Rapaglutin E inhibits cell proliferation in A549, PANC10.05, HeLa, Jurkat T, and HEK293T cells[1].
Product Specifications
Product Name Alternative
RgE
UNSPSC
12352211
Target
GLUT
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN([C@@H](CCCC)C(N[C@H](C(N1C)=O)CC2=CC3=C(C=C2)C=CC=C3)=O)C(COC4=CC([C@H](OC([C@@H]5CCCCN5C(C(C(C)(C)COC(/C=C/CCN(C)C(CNC([C@@H]1COC(C)(C)C)=O)=O)=O)=O)=O)=O)CCC6=CC(OC)=C(OC)C=C6)=CC=C4)=O
Molecular Formula
C67H88N6O15
Molecular Weight
1217.45
References & Citations
[1]Marnie Kotlyar, et al. Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1. ACS Chem Bio. 2025 Apr 14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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