Dasatinib derivative 1

Dasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma[1].

Product Specifications

CAS Number

[3079237-53-6]

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=[N+](ON=C1OCCOCCOC(CCC(OCCN2CCN(CC2)C3=NC(C)=NC(NC4=NC=C(S4)C(NC5=C(C=CC=C5Cl)C)=O)=C3)=O)=O)[O-])(C6=CC=CC=C6)=O.OS(=O)(C)=O.OS(=O)(C)=O.OS(=O)(C)=O

Molecular Formula

C41H54ClN9O20S5

Molecular Weight

1188.69

References & Citations

[1]Zhongshu Pan, et al. Identification of Nitric Oxide Donating Dasatinib Derivatives with Intraocular Pressure Lowering and Senolytic Activities. J Med Chem. 2025 Apr 24;68 (8) :8600-8617.