E3 Ligase Ligand-linker Conjugate 183

E3 Ligase Ligand-linker Conjugate 183 is an E3 ligase ligand-linker conjugate of PCSK9 autophagic degrader 2 (HY-176043) . E3 Ligase Ligand-linker Conjugate 183 consists of LC3B ligand 2 (HY-176045) and the corresponding linker (HY-141373) [1].

Product Specifications

CAS Number

[3081572-35-9]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C1N(CCOCCOCCOCCBr)C2=C(C=C(I)C=C2)/C1=C\C3=CC(Br)=C(O)C(Br)=C3

Molecular Formula

C23H23Br3INO5

Molecular Weight

760.05

References & Citations

[1]Hongyu Wu, et al. PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. J Med Chem. 2025 Apr 24;68 (8) :8190-8207.