LC3B ligand 2
LC3B ligand 2 is a ligand for E3 ubiquitin ligase. LC3B ligand 2 can be connected to the ligand for protein by a linker to form PROTAC PCSK9 autophagic degrader 2 (HY-176043) . PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C1NC2=C(C=C(I)C=C2)/C1=C\C3=CC(Br)=C(O)C(Br)=C3
Molecular Formula
C15H8Br2INO2
Molecular Weight
520.94
References & Citations
[1]Wu H, et al. PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. J Med Chem. 2025 Apr 24;68 (8) :8190-8207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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