PCSK9 autophagic degrader 2
PCSK9 autophagic degrader 2 (W6) is a PCSK9 targeted autophagosome, with an DC50 of 20.6 nM. PCSK9 autophagic degrader 2 (W6) demonstrates comparable antiatherosclerosis effect and exhibits a KD of 2.5 μM for LC3B (Pink: PCSK9 ligand HY-176044; Blue: LC3B ligand HY-176045; Black: linker HY-141373) [1].
Product Specifications
CAS Number
[2974497-11-3]
UNSPSC
12352005
Target
ATTECs; PCSK9
Related Pathways
Autophagy; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
O=C(NC1=NC=CS1)CC2(C)NCCC3=C2C=C(OCCOCCOCCOCCN4C(/C(C5=C4C=CC(I)=C5)=C/C6=CC(Br)=C(O)C(Br)=C6)=O)C(OC)=C3
Molecular Formula
C39H41Br2IN4O8S
Molecular Weight
1012.54
References & Citations
[1]Hongyu Wu, et al. PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. J Med Chem. 2025 Apr 24;68 (8) :8190-8207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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