IXA62
IXA62 is an orally active and selective IRE1/XBP1s activator (EC50 = 0.31 μM) that reduces Aβ secretion. IXA62 enhances glucose-stimulated insulin secretion from rat insulinoma cells[1].
Product Specifications
CAS Number
[956783-34-9]
UNSPSC
12352005
Target
Amyloid-β; IRE1
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Metabolic Disease; Neurological Disease
Purity
99.88
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CN1C2=CC=CC=C2C(C(CN3C(NC(C4CC4)(C3=O)C)=O)=O)=C1C5=CC=CC=C5
Molecular Formula
C24H23N3O3
Molecular Weight
401.46
References & Citations
[1]Jie Sun, et al. Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure. ACS Chem Biol. 2025 Apr 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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