DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC50 values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases[1].
Product Specifications
UNSPSC
12352005
Target
Dipeptidyl Peptidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
N[C@@H]1C(N(P(OCC)(CCSC(C=C2)=CC=C2CCCCC)=O)CCC1)=O
Molecular Formula
C20H33N2O3PS
Molecular Weight
412.53
References & Citations
[1]Sewald L, et al. Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors. Nat Commun. 2025 Apr 3;16 (1) :3208.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-8; DPP-9
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