MPO-IN-9
MPO-IN-9 is a selective inhibitor of myeloperoxidase (MPO), with an IC50 value of 3.9 nM. MPO-IN-9 inhibits MPO-mediated ROS production and protects NO-dependent vascular function by blocking MPO's chlorination and peroxidation cycles. MPO-IN-9 can be used for the study of diseases such as chronic kidney disease (CKD), non-alcoholic steatohepatitis (NASH) [1].
Product Specifications
CAS Number
[3030264-54-8]
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(C=CN2)N(CC3=CC=CN=C3[C@H]4C[C@@H](C(F)(F)F)CCN4)C(N1)=S
Molecular Formula
C18H18F3N5OS
Molecular Weight
409.43
References & Citations
[1]
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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