JAK1/TYK2-IN-5

JAK1/TYK2-IN-5 (compound A1) is a JAK1/TYK2 inhibitor with Ki values of 0.0044 nM, 0.02 nM, 6.9 μM, 0.79 μM, 0.21 μM and 0.55 μM for TYK2 JH2, JAK1 JH2, JAK1 JH1, JAK2 JH1, JAK3 JH1 and TYK2 JH1, respectiverly. JAK1/TYK2-IN-5 inhibts IFNα induced TYK2/JAK1-mediated STAT activation[1].

Product Specifications

CAS Number

[3026367-07-4]

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C(P(C5CC5)(C6CC6)=O)=C4)=C3OC)N

Molecular Formula

C26H30N7O4P

Molecular Weight

535.53

References & Citations

[1]Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 2025 Aug 21;85 (16) :3184-3201.e14.