AURKA-IN-3
AURKA-IN-3 (Compound AL8) is an irreversible covalent Aurora kinase A (AURKA) inhibitor with an IC50 value of 23.0 nM. AURKA-IN-3 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by AURKA, and reduces the autophosphorylation level of AURKA. AURKA-IN-3 is promising for research of malignant tumors associated with high AURKA expression (e.g., leukemia, lymphoma) [1].
Product Specifications
UNSPSC
12352005
Target
Aurora Kinase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(NC2=C(OC)C(C2=O)=O)C=C1)C3=CC=C(NC4=NC=C5C(C6=CC=C(Cl)C=C6C(C7=C(OC)C=CC=C7F)=NC5)=N4)C=C3OC
Molecular Formula
C38H28ClFN6O6
Molecular Weight
719.12
References & Citations
[1]Wang Z, et al. Cell-Active, Irreversible Covalent Inhibitors Targeting a Surface-Exposed Non-Catalytic Lysine on Aurora a Kinase by Using Squarate Chemistry. Angew Chem Int Ed Engl. 2025 Sep 26;64 (40) :e202510763.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A
Curated Selection
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