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TRPA1 agonist-3

TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, with EC50 values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively. TRPA1 agonist-3 does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. TRPA1 agonist-3 alleviates inflammatory pain in mice through a channel desensitization mechanism[1].

Product Specifications

CAS Number

3083086-77-2

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COCCCNC1=NC(C2=CC=C(C=C2)C)=CS1

Molecular Formula

C14H18N2OS

Molecular Weight

262.37

References & Citations

[1]Sun C, et al. Identification of a Nonelectrophilic and Selective TRPA1 Agonist for Alleviation of Inflammatory Pain through Channel Desensitization. ACS Chem Neurosci. 2025 Sep 3;16 (17) :3257-3266.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TRPA1

Frequently Asked Questions

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