Akt3 ligand-1
Akt3 ligand-1 is an Akt3 inhibitor (IC50 = 0.1 nM) and a ligand for the target protein for PROTAC (Akt3) . Akt3 ligand-1 can be used to synthesize PROTAC Akt3 Degrader-1 (HY-175975) [1].
Product Specifications
CAS Number
[2794098-49-8]
UNSPSC
12352005
Target
Akt; Ligands for Target Protein for PROTAC
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
O=C1NC2=NC=NC(N3[C@H]4C[C@H]4N(CC3)C([C@@H](C5=CC=C(C=C5)Cl)CN)=O)=C2[C@@H](C1)C
Molecular Formula
C22H25ClN6O2
Molecular Weight
440.93
References & Citations
[1]Wu YB, et al. Design, Synthesis, and Biological Evaluation of Isoform-Selective Akt3 Degraders. J Med Chem. 2025 Sep 11;68 (17) :18272-18288.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt3
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