PROTAC Akt3 Degrader-1
PROTAC Akt3 Degrader-1 is a highly efficient and selective PROTAC degrader targeting Akt3. PROTAC Akt3 Degrader-1 shows weak antiproliferative activity in 36 cell lines. PROTAC Akt3 Degrader-1 can be used for the study of Triple-negative breast cancer and melanoma[1].
Product Specifications
CAS Number
[3048204-93-6]
UNSPSC
12352005
Target
Akt; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
O=C1NC2=NC=NC(N3[C@H]4C[C@H]4N(CC3)C([C@@H](C5=CC=C(C=C5)Cl)CNC(CCCCCCCCCCC6=C(C7=CC=C6)CN(C7=O)C8CCC(NC8=O)=O)=O)=O)=C2[C@@H](C1)C
Molecular Formula
C46H55ClN8O6
Molecular Weight
851.43
References & Citations
[1]Wu YB, et al. Design, Synthesis, and Biological Evaluation of Isoform-Selective Akt3 Degraders. J Med Chem. 2025 Sep 11;68 (17) :18272-18288.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt3
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