Antitrypanosomal agent 27

Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI50 of 31 nM. Antitrypanosomal agent 27 shows the selectivity index ≥ 50 for human liver cancer HepG2 cells , and has no significant cytotoxicity. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis[1].