Antitrypanosomal agent 27

Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI50 of 31 nM. Antitrypanosomal agent 27 shows the selectivity index ≥ 50 for human liver cancer HepG2 cells , and has no significant cytotoxicity. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis[1].

Product Specifications

CAS Number

[2148927-96-0]

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

CN1CCN(CC1)C2=CC=CC(C3=CC=C4N=CN=C(C4=C3)NC5=CC=C(C(C(F)(F)F)=C5)[N+]([O-])=O)=C2

Molecular Formula

C26H23F3N6O2

Molecular Weight

508.50

References & Citations

[1]Spijkers-Shaw S, et al. Optimization of Quinazolines for Inhibition of Trypanosoma brucei Proliferation. ACS Med Chem Lett. 2025 Aug 22;16 (9) :1806-1813.