Antitrypanosomal agent 27
Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI50 of 31 nM. Antitrypanosomal agent 27 shows the selectivity index ≥ 50 for human liver cancer HepG2 cells , and has no significant cytotoxicity. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis[1].
Product Specifications
CAS Number
2148927-96-0
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CN1CCN(CC1)C2=CC=CC(C3=CC=C4N=CN=C(C4=C3)NC5=CC=C(C(C(F)(F)F)=C5)[N+]([O-])=O)=C2
Molecular Formula
C26H23F3N6O2
Molecular Weight
508.50
References & Citations
[1]Spijkers-Shaw S, et al. Optimization of Quinazolines for Inhibition of Trypanosoma brucei Proliferation. ACS Med Chem Lett. 2025 Aug 22;16 (9) :1806-1813.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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