PDE1-IN-10
PDE1-IN-10 is a potent and sekective Phosphodiesterase 1 (PDE1) inhibitor with an IC50 of 5 nM. PDE1-IN-10 can suppress TGF-β/Smad-MAPK signaling and exhibit antifibrotic effects. PDE1-IN-10 can be used for the research of idiopathic pulmonary fibrosis[1].
Product Specifications
UNSPSC
12352005
Target
P38 MAPK; Phosphodiesterase (PDE) ; TGF-beta/Smad
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(C=C1)CC2=CC(/C(O3)=C/C4=CC(F)=CC=C4OC(C)C)=C(C(N2)=O)C3=O
Molecular Formula
C24H19F2NO4
Molecular Weight
423.41
References & Citations
[1]Jiang MY, et al. Discovery of Selective PDE1 Inhibitors Alleviating Pulmonary Fibrosis by the Regulation of TGF-β/Smads and MAPK Pathways. J Med Chem. 2025 Sep 11;68 (17) :18423-18435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1
Frequently Asked Questions
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