PDE1-IN-10

PDE1-IN-10 is a potent and sekective Phosphodiesterase 1 (PDE1) inhibitor with an IC50 of 5 nM. PDE1-IN-10 can suppress TGF-β/Smad-MAPK signaling and exhibit antifibrotic effects. PDE1-IN-10 can be used for the research of idiopathic pulmonary fibrosis[1].

Product Specifications

UNSPSC

12352005

Target

P38 MAPK; Phosphodiesterase (PDE) ; TGF-beta/Smad

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

FC1=CC=C(C=C1)CC2=CC(/C(O3)=C/C4=CC(F)=CC=C4OC(C)C)=C(C(N2)=O)C3=O

Molecular Formula

C24H19F2NO4

Molecular Weight

423.41

References & Citations

[1]Jiang MY, et al. Discovery of Selective PDE1 Inhibitors Alleviating Pulmonary Fibrosis by the Regulation of TGF-β/Smads and MAPK Pathways. J Med Chem. 2025 Sep 11;68 (17) :18423-18435.