Pomalidomide-C9-Br
Pomalidomide-C9-Br is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC EGFR degrader 15 (HY-175839) . PROTAC EGFR degrader 15 is a potent EGFR PROTAC degrader with anti-cancer activity[1].
Product Specifications
CAS Number
[2545963-23-1]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(N1)CCC(N2C(C(C(NC(CCCCCCCCCBr)=O)=CC=C3)=C3C2=O)=O)C1=O
Molecular Formula
C23H28BrN3O5
Molecular Weight
506.39
References & Citations
[1]Li L, et al. A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation. Bioorg Chem. 2025 Sep;164:108864.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175887/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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