PROTAC FTO degrader 1

PROTAC FTO degrader 1 is a Fat Mass and Obesity-associated Protein (FTO) PROTAC degrader. PROTAC FTO degrader 1 selectively degrades FTO depending on VHL E3 ligase and ubiquitin-proteasome system. PROTAC FTO degrader 1 can increase m6A modifications on mRNAs associated with ribosome biogenesis and promote their YTHDF2-mediated decay. PROTAC FTO degrader 1 can inhibit cancer cells proliferation and induce apoptosis. PROTAC FTO degrader 1 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1]. (Structure Note: Pink: FTO ligand (HY-175886) ; Blue: VHL ligand (HY-112078) ; Black: linker (HY-W002042) ; VHL ligand-Linker: (HY-139218) )

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; Fat Mass and Obesity-associated Protein (FTO) ; PARP; PROTACs; YTHDF

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Smiles

CC(C(OCOC(C1=C(C=CC=C1NC(C(Cl)=CC(C(C(C)=NO2)=C2C)=C3)=C3Cl)N4CCN(CC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)CC4)=O)=O)C