AMG-34
AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and > 10 μM for GCN2, PERK, HRland PKR, respectively[1].
Product Specifications
CAS Number
[1644664-11-8]
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CN(N(C1=CC=CC=C1)C2=O)C(C3=CC=CC=C3)=C2C(C4=CC=C(C)C(C5=C(F)C6=CN=C(NC)N=C6C=C5)=C4N)=O
Molecular Formula
C33H27FN6O2
Molecular Weight
558.60
References & Citations
[1]Tameire F, et al. In Vivo Tumor Growth Control by General Control Nonderepressible 2-Targeting Agents Results from Kinase Activation. Mol Cancer Ther. 2025 Sep 5:OF1-OF13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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