SARM1-IN-7

SARM1-IN-7 is a potent active site (orthosteric) and orally active SARM1 inhibitor. SARM1-IN-7 continuously activates the enzymatic activity of SARM1, thereby exacerbating the depletion of NAD at sub-minimal concentrations. SARM1-IN-7 demonstrated dual benefits in the SARM1-activated cell models and mouse models: a high dose exerted a cell/neuron protective effect, while a low dose exacerbated cell/neuron damage. SARM1-IN-7 can be used for the study of axon degeneration[1].

Product Specifications

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Smiles

C[C@H](N(C)C(NC(F)(F)F)=O)C1=CC=NC=C1

Molecular Formula

C10H12F3N3O

Molecular Weight

247.22

References & Citations

[1]Leahey, R.R, et al. Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration. npj Drug Discov. 2, 21 (2025) .