ADAM17-IN-1

ADAM17-IN-1 is a selective inhibitor of ADAM17. ADAM17-IN-1 inhibits ADAM17 activity to reduce metabolic activity of dendritic cells (DCs), impair DC antigen-presenting function, suppress allergen-specific Th2 cell polarization, and reduce Th2 cytokine (IL-4, IL-5, IL-13) secretion. ADAM17-IN-1 demonstrates protective efficacy against house dust mite (HDM) -induced type 2/eosinophilic airway inflammation in mice. ADAM17-IN-1 can be used for the study of type 2-high allergic asthma[1].

Product Specifications

CAS Number

[1802395-34-1]

UNSPSC

12352005

Target

Interleukin Related; MMP

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

CCC[C@@H](CNC(C1=O)=O)N1C[C@H](CCC2)N2C[C@H](N3C[C@@H](N(C(C3=O)=O)CCC4=CC=CC=C4)CC5=CC=CC=C5)CC6CCCCC6

Molecular Formula

C40H55N5O4

Molecular Weight

669.90

References & Citations

[1]Jaiswal AK, et al. Targeting ADAM17 to dampen dendritic cell-mediated type 2 immune responses and airway inflammation associated with allergic asthma. Sci Rep. 2025 Aug 25;15 (1) :31253.