HRZ-01-082-5

HRZ-01-082-5 is an analog of Glutarimide (HY-I0466) . HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8 nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research[1].

Product Specifications

CAS Number

[3090685-19-8]

UNSPSC

12352005

Target

Drug Derivative; Molecular Glues; Zinc Finger Protein

Related Pathways

Cell Cycle/DNA Damage; Others; PROTAC

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(C4=C(NC56CC7CC(C6)CC(C5)C7)N8N=CSC8=N4)C=C3C2=O)=O)=O

Molecular Formula

C27H26N6O4S

Molecular Weight

530.60

References & Citations

[1]Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 2025 Aug 21;85 (16) :3184-3201.e14.