Tubulin-IN-55
Tubulin-IN-55 is a tubulin inhibitor. Tubulin-IN-55 disrupts the PI3K/Akt signaling pathway in cancer cells. Tubulin-IN-55 exerts broad-spectrum anti-proliferative activity against multiple tumor cells (HeLa, HCT116, 4T1, A549, H1299, MDA-MB231) . Tubulin-IN-55 induces G2/M phase arrest and apoptosis, and inhibits tumor cell migration/invasion in cancer cells. Tubulin-IN-55 demonstrates potent antitumor efficacy in orthotopic autologous transplantation mice. Tubulin-IN-55 can be used for the study of cancer[1].
Product Specifications
CAS Number
353258-94-3
UNSPSC
12352005
Target
Akt; Apoptosis; Microtubule/Tubulin; PI3K
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(N1CCN(CC1)C2=CC=CC=C2)C3=CC=CN=C3N4CCCCC4
Molecular Formula
C21H26N4O
Molecular Weight
350.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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