Tubulin-IN-55

Tubulin-IN-55 is a tubulin inhibitor. Tubulin-IN-55 disrupts the PI3K/Akt signaling pathway in cancer cells. Tubulin-IN-55 exerts broad-spectrum anti-proliferative activity against multiple tumor cells (HeLa, HCT116, 4T1, A549, H1299, MDA-MB231) . Tubulin-IN-55 induces G2/M phase arrest and apoptosis, and inhibits tumor cell migration/invasion in cancer cells. Tubulin-IN-55 demonstrates potent antitumor efficacy in orthotopic autologous transplantation mice. Tubulin-IN-55 can be used for the study of cancer[1].

Product Specifications

CAS Number

[353258-94-3]

UNSPSC

12352005

Target

Akt; Apoptosis; Microtubule/Tubulin; PI3K

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(N1CCN(CC1)C2=CC=CC=C2)C3=CC=CN=C3N4CCCCC4

Molecular Formula

C21H26N4O

Molecular Weight

350.46

References & Citations

[1]Shan P, et al. Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy. Cell Death Discov. 2025 Aug 19;11 (1) :392.