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14-3-3σ/ERα stabilizer-2

14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a Kd of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research[1].

Product Specifications

UNSPSC

12352005

Target

Estrogen Receptor/ERR; Molecular Glues

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Smiles

CC1=C(NC2=C(C3=CC=C(NC(CCl)=O)C=C3F)N=C4N2C=C(C)C=C4)C(C)=CC=C1

Molecular Formula

C24H22ClFN4O

Molecular Weight

436.91

References & Citations

[1]Konstantinidou M, et al. Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex. Nat Commun. 2025 Jul 14;16 (1) :6467.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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