Eras-4001
Eras-4001 (Compound 14-1) is a pan-KRAS inhibitor. Eras-4001 has potent antitumor activities and significantly inhibits the proliferation of wild-type and mutant (such as KRASG12D, KRASG12V and KRASG12C) cancer cells. Eras-4001 effectively inhibits tumor growth in GP2D and Panc0403 xenograft mouse models[1].
Product Specifications
CAS Number
[3024878-19-8]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC1=C([C@@H]2CC(N=C(OC[C@@]34CCCN3CC(C4)=C)N=C5N6CC7=C(Cl)C(C(N(C)C)=O)=NN7CCC6)=C5CO2)C(C(F)(F)F)=C(C#CC)C=C1N
Molecular Formula
C36H39ClF4N8O3
Molecular Weight
743.19
References & Citations
[1]Zhang Y, et al. Heterocyclic substituted pyrimidopyran compound and use thereof. WO2023246914A1. 2023-12-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
HEY1 (Hairy/Enhancer-of-Split Related with YRPW Motif 1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, MGC1274, OAF1) (MaxLight 490)
E2F-1 (Transcription Factor E2F1, E2F-1, PBR3, Retinoblastoma-Associated Protein 1, RBAP-1, Retinoblastoma-Binding Protein 3, RBBP-3, pRB-Binding Protein E2F-1, E2F1, RBBP3) discontinued
E2F-1 (Transcription Factor E2F1, E2F-1, PBR3, Retinoblastoma-Associated Protein 1, RBAP-1, Retinoblastoma-Binding Protein 3, RBBP-3, pRB-Binding Protein E2F-1, E2F1, RBBP3) discontinued