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PROTAC SMARCA2 degrader-34

PROTAC SMARCA2 degrader-34 (compound 52) is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: SMARCA2, > 1 μM for SMARCA4) . PROTAC SMARCA2 degrader-34 can be used for study of cancer. (Pink: SMARCA2 ligand (HY-178414) ; Blue: E3 ligand (HY-168055) ; Black: linker) [1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Related Pathways

Epigenetics; PROTAC

Field of Research

Cancer

Smiles

FC([C@]12N(C[C@H](N3C4=C(CN(CC5CCN(C6=CC=C(CN([C@@H]7C(NC(CC7)=O)=O)C8=O)C8=C6)CC5)C(C)C4)C=N3)C2)C9=CC(C%10=C(C(F)=CC=C%10)O)=NN=C9NC1)F

Molecular Formula

C42H45F3N10O4

Molecular Weight

810.87

References & Citations

[1]Artem SHVARTSBART, et al. Brm targeting compounds and associated methods of use. WO2025101738A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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