Aurora kinase-IN-8

Aurora kinase-IN-8 is a orally active Aurora kinase inhibitor. Aurora kinase-IN-8 shows IC50 values of 2.8 and 28.1 nM against Aurora A kinase and Aurora B kinase. Aurora kinase-IN-8 can prevent spindle formation, cause G2/M phase arrest, and induce cell apoptosis. Aurora kinase-IN-8 can be used for the research of cancer, such as triple-negative breast cancer[1].

Product Specifications

CAS Number

[1911629-44-1]

UNSPSC

12352005

Target

Apoptosis; Aurora Kinase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CN(CC1)CCN1C(C=C2)=CC3=C2C(NC4=NNC(C)=C4)=NC(/C=C/C5=CC=CC=C5)=N3

Molecular Formula

C25H27N7

Molecular Weight

425.53

References & Citations

[1]Long L, et al. Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Sep 11;68 (17) :18197-18215.