Aurora kinase-IN-8
Aurora kinase-IN-8 is a orally active Aurora kinase inhibitor. Aurora kinase-IN-8 shows IC50 values of 2.8 and 28.1 nM against Aurora A kinase and Aurora B kinase. Aurora kinase-IN-8 can prevent spindle formation, cause G2/M phase arrest, and induce cell apoptosis. Aurora kinase-IN-8 can be used for the research of cancer, such as triple-negative breast cancer[1].
Product Specifications
CAS Number
1911629-44-1
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CN(CC1)CCN1C(C=C2)=CC3=C2C(NC4=NNC(C)=C4)=NC(/C=C/C5=CC=CC=C5)=N3
Molecular Formula
C25H27N7
Molecular Weight
425.53
References & Citations
[1]Long L, et al. Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Sep 11;68 (17) :18197-18215.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B
Available Sizes
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