HSP70-IN-7
HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs) . HSP70-IN-7 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HSP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN(CCNC(C1=C2C3=CC=CC2=C(C=C1)SC4CCCCC4)=C(C3=O)C#N)CCNC(CCCCCCCCCCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O.[Br-]
Molecular Formula
C55H66BrN4O2PS
Molecular Weight
958.08
References & Citations
[1]Jiang M, et al. Revealing GRP75-Mediated Mitochondrial Stability That Promotes Breast Cancer Survival through Subcellular Anchoring of 70 kDa Heat Shock Protein Inhibitors. J Med Chem. 2025 Sep 25;68 (18) :19169-19183.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70
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