ALR2-IN-9

ALR2-IN-9 is a potent ALR2 inhibitor (IC50 = 21.8 nM) with excellent antioxidant activity (EC50 for DPPH radical scavenging = 2.8 μM) . ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS) /Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO4- and H2O2-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research[1].

Product Specifications

CAS Number

[2135481-84-2]

UNSPSC

12352005

Target

Akt; Aldose Reductase; Keap1-Nrf2; p38 MAPK; PI3K; Reactive Oxygen Species (ROS) ; SOD

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

CC(N[C@H](COCC1=CC=CC=C1)C(NCCCNC(/C(C#N)=C/C2=CC(O)=C(C=C2)O)=O)=O)=O

Molecular Formula

C25H28N4O6

Molecular Weight

480.51

References & Citations

[1]Liu L, et al. Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation. Bioorg Chem. 2025 Sep;164:108886.