NSC20116
NSC20116 is a uracil derivative that specifically targets the Set-and-Ring (SRA) domain of the oncogene UHRF1. NSC20116 binds to the 5-methylcytosine (5mC) (HY-W008091) recognition pocket of UHRF1 SRA domain, with a dissociation constant (Kd) of 362 nM. NSC20116 can be used for the study of cancer[1].
Product Specifications
CAS Number
[644-37-1]
UNSPSC
12352005
Target
Drug Derivative; E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=NNC1=CNC(NC1=O)=O
Molecular Formula
C4H4N4O3
Molecular Weight
156.10
References & Citations
[1]Akrani I, et al. Discovery and Characterization of Uracil Derivatives Targeting the Set-and-Ring Domain of UHRF1. J Chem Inf Model. 2025 Sep 8;65 (17) :9274-9286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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