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NSC20116

NSC20116 is a uracil derivative that specifically targets the Set-and-Ring (SRA) domain of the oncogene UHRF1. NSC20116 binds to the 5-methylcytosine (5mC) recognition pocket of UHRF1 SRA domain, with a dissociation constant (Kd) of 362 nM. NSC20116 can be used for the study of cancer[1].

Product Specifications

CAS Number

644-37-1

UNSPSC

12352005

Target

Drug Derivative; E1/E2/E3 Enzyme

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=NNC1=CNC(NC1=O)=O

Molecular Formula

C4H4N4O3

Molecular Weight

156.10

References & Citations

[1]Akrani I, et al. Discovery and Characterization of Uracil Derivatives Targeting the Set-and-Ring Domain of UHRF1. J Chem Inf Model. 2025 Sep 8;65 (17) :9274-9286.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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