KRAS G12D ligand-Linker Conjugate 2
KRAS G12D ligand-Linker Conjugate 2 is a conjugate of the KRAS (G12D) ligand (HY-175859) and the linker (HY-168698) . KRAS G12D ligand-Linker Conjugate 2 can be used for synthesizing PROTAC KRAS (G12D) degrader ASP-3082 (HY-157505) [1].
Product Specifications
UNSPSC
12352005
Target
Ras; Target Protein Ligand-Linker Conjugates
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
CC1=[C@]([C@](C(C2CC2)=CC3=C4N=C(N=C3N5C[C@@H]6C[C@H]5CN6)OC7CCOCC7)=C4OCC8=CC=C(C#C)C=C8)C(C=NN9)=C9C=C1F
Molecular Formula
C38H37FN6O3
Molecular Weight
644.74
References & Citations
[1]Yoshinari T, et al. Discovery of KRAS (G12D) selective degrader ASP3082. Commun Chem. 2025 Aug 23;8 (1) :254.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Curated Selection
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