AChE-IN-95

AChE-IN-95 (Compound 7) is a highly selective competitive acetylcholinesterase (AChE) inhibitor (IC50=17.87 μM, Ki=19.48 μM) . AChE-IN-95 exhibits strong cytotoxicity against SH-SY5Y neuroblastoma cells. AChE-IN-95 is promising for research of Alzheimer’s disease and neurodegenerative disorders[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

COC1=CC=CC(NC(CN2C(/C(SC2=O)=C/C3=CC(CN4CCN(C5=CC=CC=C5)CC4)=C(O)C(OC)=C3)=O)=O)=C1

Molecular Formula

C31H32N4O6S

Molecular Weight

588.67

References & Citations

[1]Turgut GÇ, et al. Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluations. Bioorg Chem. 2025 Sep;164:108869.