Topoisomerase II-IN-24
Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC50 of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer[1].
Product Specifications
CAS Number
[613254-63-0]
UNSPSC
12352005
Target
Apoptosis; Caspase; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(N/N=C/C=C/C1=CC=CC=C1)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O
Molecular Formula
C27H23ClN4O2S2
Molecular Weight
535.08
References & Citations
[1]Hassan RA, et al. Thieno[2,3-d]pyrimidine derivatives as topoisomerase II inhibitors: design, synthesis, anticancer evaluation, and in silico studies. Bioorg Chem. 2025 Aug 6;164:108839.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Topo II
Curated Selection
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