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Topoisomerase II-IN-24

Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC50 of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer[1].

Product Specifications

CAS Number

613254-63-0

UNSPSC

12352005

Target

Apoptosis; Caspase; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(N/N=C/C=C/C1=CC=CC=C1)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O

Molecular Formula

C27H23ClN4O2S2

Molecular Weight

535.08

References & Citations

[1]Hassan RA, et al. Thieno[2,3-d]pyrimidine derivatives as topoisomerase II inhibitors: design, synthesis, anticancer evaluation, and in silico studies. Bioorg Chem. 2025 Aug 6;164:108839.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3; Topo II

Frequently Asked Questions

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