Ferroptosis inducer-11
Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC50 of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid ROS, malondialdehyde (MDA), and Fe2+ levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@@H]2[C@](/C=C/C=C(C)/C(N3CCN(C(C#C)=O)CC3)=O)(C)O4)(CC2)C4=O)OC
Molecular Formula
C30H36N2O8
Molecular Weight
552.62
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Frequently Asked Questions
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