Ferroptosis inducer-11

Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC50 of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid ROS, malondialdehyde (MDA), and Fe2+ levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@@H]2[C@](/C=C/C=C(C)/C(N3CCN(C(C#C)=O)CC3)=O)(C)O4)(CC2)C4=O)OC

Molecular Formula

C30H36N2O8

Molecular Weight

552.62

References & Citations

[1]Zhang L, et al. Design, synthesis, and biological evaluation of Pseudolaric acid B derivatives as Ferroptosis inducers in Colon Cancer cells. Bioorg Chem. 2025 Sep;164:108852.