A2AAR antagonist 5
A2AAR antagonist 5 is a selective A2AAR antagonist. A2AAR antagonist 5 inhibits NECA-stimulated adenylyl cyclase activity in hA2AAR-expressing CHO cells with an IC50 value of 1863 nM. A2AAR antagonist 5 possesses strong free radical scavenging activity, with an EC50 value of 22.21 μM in the DPPH assay. A2AAR antagonist 5 exerts notable neuroprotective effects in in vitro cerebral ischemia models. A2AAR antagonist 5 can be used for the study of cerebral ischemia[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC=C(C2=CN3C(C(N)=N2)=NN(C4=CC=CC=C4)C3=O)C=C1)CN5N=C(C)CC5=O
Molecular Formula
C23H20N8O3
Molecular Weight
456.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)
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