NSC 850745
NSC 850745 is a selective and potent c-Met/STAT3 inhibitor with IC50 values of 210 and 670 nM. NSC 850745 can inhibit cell proliferation, induce G2/M phase arrest and induce apoptosis. NSC 850745 can downregulate AKT-1, VEGF and Bcl-2 expression and upregulate p53, Bax and caspase expression. NSC 850745 can be used for the research of cancer, such as leukemia and colon cancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; c-Met/HGFR; MDM-2/p53; STAT; VEGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(CN1CCN(CC1)C2=C3C(N(N=C3)C4=CC=CC=C4)=NC=N2)NCC5=CC=CC=C5
Molecular Formula
C24H25N7O
Molecular Weight
427.50
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1; Bcl-2; Caspase 3; Caspase 8; Caspase 9; Met; STAT3
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