TQFL13

TQFL13 is derivative of Thymoquinone (TQ) (HY-D0803) with potent anti-breast cancer activity. TQFL13 exhibits higher cytotoxicity against breast cancer cells (BT549, MDA-MB-231, 4T1) . TQFL13 increases apoptosis and blocks the cell cycle at S and G2/G1 phases in breast cancer cells. TQFL13 shows dose-dependent anti-tumor efficacy in mouse breast cancer allograft model. TQFL13 can be used for the study of breast cancer[1].

Product Specifications

CAS Number

[2822560-46-1]

UNSPSC

12352005

Target

Apoptosis; Drug Derivative

Related Pathways

Apoptosis; Others

Field of Research

Cancer

Smiles

COC1=CC=C(C(OC)=C1OC)/C=N/C2=C(C(C=C(C2=O)C(C)C)=O)C

Molecular Formula

C20H23NO5

Molecular Weight

357.40

References & Citations

[1]Wei C, et al. TQFL13, a novel synthetic derivative of thymoquinone (TQ), is more capable of inhibiting breast cancer progression than TQ. Bioorg Chem. 2025 Sep;164:108837.