Scr-IN-2

Scr-IN-2 is an effective c-Scr inhibitor with an IC50 of 302 nM. Scr-IN-2 exhibits nanomolar-level anti-breast cancer activity. Scr-IN-2 increases the level of ROS in cells, induces mitochondrial damage, G1 phase arrest, and apoptosis. Scr-IN-2 can be used in the research of breast cancer[1].

Product Specifications

CAS Number

2787582-78-7

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS) ; Src

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CCCCN1C(NC(C)(C)C)=NC2=CC=CC=C2C1C3=NN=NN3C(C)(C)C

Molecular Formula

C21H33N7

Molecular Weight

383.53

References & Citations

[1]Zou L, et al. Design and synthesis of tetrazole tethered quinazoline derivatives via azide-isocyanide cross-coupling reaction: Exploring the utility as anticancer agents via the SRC kinase inhibition in breast cancer. Bioorg Chem. 2025 Sep;164:108844.