ROCK2-IN-10

ROCK2-IN-10 is a potent and selective ROCK2 inhibitor (IC50 = 0.020 μM) with 41-fold selectivity over isoform ROCK1. ROCK2-IN-10 inhibits metastasis by disrupting the cytoskeleton, independent of proliferative suppression. ROCK2-IN-10 shows superior inhibitory potency against cancer cell metastasis, which closely related to the suppression of STAT3 phosphorylation. ROCK2-IN-10 can be used for breast cancer metastasis research[1].

Product Specifications

UNSPSC

12352005

Target

ROCK; STAT

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC(C=C1)=CC=C1NC(OC[C@H](CCC2)N2C3=NC(NC4=CC5=C(C=C4)NN=C5)=CC=C3NC(CNC6CCCC6)=O)=O

Molecular Formula

C32H38N8O3

Molecular Weight

582.70

References & Citations

[1]Zhang J, et al. Design and synthesis of ROCK2-selective inhibitors bearing 6-indazolamino-2-pyrrolidinylpyridine for the treatment of breast cancer metastasis. Bioorg Chem. 2025 Sep;164:108862.