Tau Protein Phosphorylation-IN-1

Tau Protein Phosphorylation-IN-1 is a tau protein phosphorylation inhibitor that potently protects PC12 cells against Aβ25–35-induced cytotoxicity (EC50 = 1.93 μM), and can penetrate the blood-brain barrier (BBB) .Tau Protein Phosphorylation-IN-1 reverses the hyperphosphorylation of tau, significantly inhibits the expression of certain immune-related cytotoxic factors, suppresses the MAPK and NF-κB signaling pathways, and significantly inhibits the expression of RAGE and the apoptosis factors Bax/Bcl-2, both in vitro and in vivo. Tau Protein Phosphorylation-IN-1 relieves nerve damage, and improves learning and memory in an Alzheimer’s disease (AD) mouse model. Tau Protein Phosphorylation-IN-1 can be used for AD research[1].

Product Specifications

CAS Number

[3075165-36-2]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; ERK; JNK; NF-κB; p38 MAPK; Tau Protein

Related Pathways

Apoptosis; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

O=C([C@]12[C@](CC(C)(CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC5)C)([H])[C@]5(C)[C@@]3(CC1)C)OCCN6C(C7=CC=CC=C7)=NN=N6

Molecular Formula

C39H56N4O3

Molecular Weight

628.89

References & Citations

[1]Liu Z, et al. Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25-35 in vitro and in vivo. Bioorg Chem. 2025 Sep;164:108866.