PROTAC EGFR degrader 15
PROTAC EGFR degrader 15 is a Pomalidomide -based Gefitinib (HY-50895) EGFR PROTAC degrader. PROTAC EGFR degrader 15 triggers EGFR degradation via ubiquitin-proteasome-dependent proteolysis and autophagy-lysosome activation pathways. PROTAC EGFR degrader 15 targets ETFA to enhance ATP production. PROTAC EGFR degrader 15 significantly suppresses tumor growth in a Gefitinib-acquired resistant HCC-827 xenograft model. PROTAC EGFR degrader 15 can be used for the study of non-small cell lung cancer (NSCLC) (Pink: EGFR ligand (HY-W109039) ; Blue: CRBN ligand (HY-10984) ; Black: Linker (HY-W679737) ).
Product Specifications
UNSPSC
12352005
Target
ATP Synthase; EGFR; PROTACs
Related Pathways
JAK/STAT Signaling; Membrane Transporter/Ion Channel; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
97.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1)CCC(N2C(C(C(NC(CCCCCCCCCN3CCN(CCCOC4=CC(C(NC5=CC(Cl)=C(F)C=C5)=NC=N6)=C6C=C4OC)CC3)=O)=CC=C7)=C7C2=O)=O)C1=O
Molecular Formula
C45H52ClFN8O7
Molecular Weight
871.40
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Frequently Asked Questions
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