EGFR-IN-172
EGFR-IN-172 is a EGFR inhibitor. EGFR-IN-172 effectively inhibits the proliferation of non-small cell lung cancer (NSCLC) cells carrying the L858R, T790M and C797S drug-resistant mutations. EGFR-IN-172 inhibits EGFR phosphorylation, induces cell cycle arrest and apoptosis. EGFR-IN-172 can be used for the study of NSCLC[1].
Product Specifications
CAS Number
878416-74-1
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(F)=C3)NC4=NC=CC(C)=C4
Molecular Formula
C22H18FN3O
Molecular Weight
359.40
References & Citations
[1]Xu X, et al. Design and synthesis of Betti base derivatives as EGFR inhibitors. Bioorg Chem. 2025 Sep;164:108872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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