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EGFR-IN-172

EGFR-IN-172 is a EGFR inhibitor. EGFR-IN-172 effectively inhibits the proliferation of non-small cell lung cancer (NSCLC) cells carrying the L858R, T790M and C797S drug-resistant mutations. EGFR-IN-172 inhibits EGFR phosphorylation, induces cell cycle arrest and apoptosis. EGFR-IN-172 can be used for the study of NSCLC[1].

Product Specifications

CAS Number

878416-74-1

UNSPSC

12352005

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(F)=C3)NC4=NC=CC(C)=C4

Molecular Formula

C22H18FN3O

Molecular Weight

359.40

References & Citations

[1]Xu X, et al. Design and synthesis of Betti base derivatives as EGFR inhibitors. Bioorg Chem. 2025 Sep;164:108872.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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