CYP1B1-IN-12
CYP1B1-IN-12 is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 6.05 nM. CYP1B1-IN-12 demonstrates remarkable selectivity, exceeding 1600-fold and 16,000-fold over CYP1A1 and CYP1A2, respectively. CYP1B1-IN-12 can enhance Paclitaxel (HY-B0015) -mediated apoptosis and restore Paclitaxel sensitivity in A549/Taxol-resistant cells. CYP1B1-IN-12 can inhibit the epithelial-mesenchymal transition process and reduce cells migration and invasion. CYP1B1-IN-12 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Cytochrome P450
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
IC1=CC=C(C=C1)C2=NOC(C3=NC(C4=CC=CC=C4)=CS3)=N2
Molecular Formula
C17H10IN3OS
Molecular Weight
431.25
References & Citations
[1]Li C, et al. Discovery of novel selective CYP1B1 inhibitors: Design, synthesis and biological evaluation. Bioorg Chem. 2025 Sep;164:108838.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
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