PROTAC AURKA degrader 1
PROTAC AURKA degrader 1 (Compound A16 + X7) is a Aurora kinase A (AURKA) PROTAC degrader. PROTAC AURKA degrader 1 can be used for cancers research[1]. Pink: AURKA ligand (HY-175827) ; Blue: CRBN ligase ligand (HY-W867704) ; Black: linker (HY-132208)
Product Specifications
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(C1(CC2=NC(NC3=NC=CS3)=CC=C2)CCC(OC4=CC=CC(Cl)=C4F)CC1)NCCOCCOCC5=CN(CCOCCOCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)N=N5
Molecular Formula
C48H54ClFN10O10S
Molecular Weight
1017.52
References & Citations
[1]Mitrovic M, et al. Click. Screen. Degrade. A Miniaturized D2B Workflow for rapid PROTAC Discovery[J]. bioRxiv, 2025: 2025.07. 29.667383.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A
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