DHPS-IN-2

DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC50 of 70 nM and a Kd of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma[1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

IC1=CC=C(C=C1)CC2=NN=C(CC3=CC=CC=C3OC)O2

Molecular Formula

C17H15IN2O2

Molecular Weight

406.22

References & Citations

[1]Liu KL, et al. In silico design, synthesis and biological evaluation of 2-benzyl-5- (2-methoxybenzyl) -1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment. Eur J Med Chem. 2025 Dec 5;299:118061.