PSD-95/nNOS PPI-IN-1

PSD-95/nNOS PPI-IN-1 is a inhibitor targeting the PSD-95/nNOS interaction with potential blood-brain barrier penetration. PSD-95/nNOS PPI-IN-1 binds to the PSD-95 PDZ2 domain with high affinity (Ki = 19.45 μM) . PSD-95/nNOS PPI-IN-1 inhibits glutamate-induced excitotoxicity by reducing intracellular ROS levels and inhibiting apoptosis. PSD-95/nNOS PPI-IN-1 significantly reduces cerebral infarct volume in rat tMCAO models. PSD-95/nNOS PPI-IN-1 can be used for the study of acute ischemic stroke[1].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; iGluR; NO Synthase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

S=C(C[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(NC1=CC=CC=C1)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)C2)N2C3=CC=C(OC)C=C3

Molecular Formula

C32H41N5O8S

Molecular Weight

655.76

References & Citations

[1]Wang J, et al. Development of cell-permeable and plasma-stable peptidomimetic inhibitors against PSD-95/nNOS interaction as potential anti-ischemic stroke agents. Eur J Med Chem. 2025 Dec 5;299:118062.