PSD-95/nNOS PPI-IN-1
PSD-95/nNOS PPI-IN-1 is a inhibitor targeting the PSD-95/nNOS interaction with potential blood-brain barrier penetration. PSD-95/nNOS PPI-IN-1 binds to the PSD-95 PDZ2 domain with high affinity (Ki = 19.45 μM) . PSD-95/nNOS PPI-IN-1 inhibits glutamate-induced excitotoxicity by reducing intracellular ROS levels and inhibiting apoptosis. PSD-95/nNOS PPI-IN-1 significantly reduces cerebral infarct volume in rat tMCAO models. PSD-95/nNOS PPI-IN-1 can be used for the study of acute ischemic stroke[1].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; iGluR; NO Synthase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
S=C(C[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(NC1=CC=CC=C1)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)C2)N2C3=CC=C(OC)C=C3
Molecular Formula
C32H41N5O8S
Molecular Weight
655.76
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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